Pablo V. Romero MD, PhD

Since 1978, Dr. Pablo V Romero Colomer has directed the Pulmonary Function Laboratory at the University Hospital of Bellvitge (HUB). In 1992 he became head of the Respiration Pathophysiology Unit in the Department of Pneumology and Director of the Experimental Pneumology Laboratory at the Bellvitge Institute of Biomedical Research (IDIBELL), University of Barcelona. He is currently a Senior Research Scientist at IDIBELL. From 1972 to 1974 he studied pneumology and pathophysiology in the “Service de Médécine Orienté vers l’Insuffissance Respiratoire” at Centre Hospitalier de Nancy-Brabois (Prof. Paul Sadoul). As a researcher, he was initially interested in the study of factors limiting exercise in COPD patients, and in 1978, he obtained a PhD “cum laude” on this subject from the University of Valencia (Spain) . He subsequently became interested in bronchial hyperresponsiveness (from the epidemiological, pathophysiological, therapeutical and experimental perspectives) and pulmonary mechanics (both pathophysiological and experimental). In 1988 he spent a sabbatical year as research fellow at the Meakins Christie Laboratories, McGill University of Montreal (Prof. J. Milic-Emili), where he collaborated with J. Bates, M. Ludwig and J. Fredberg. Other areas of interest in his research have been volumetric capnography and sleep apnea. During his professional life has collaborated with, often visited, and always learned from notable scientists. As Director of the Pulmonary Function Laboratory, he soon became interested in artificial intelligence and computational methods applied to functional diagnosis and he has recently been led by that interest to develop this present project.


BIBLIOGRAPHY (Selection)

Exercise:

Jiménez M, Romero Colomer P, Hennequin R, Saunier C. [Arterial lactate levels and pulmonary haemodynamics during moderate exercise in chronic respiratory insufficiency] Bull Physiopathol Respir. 1974; 10(3): 281-300. French.

Romero Colomer P, Schrijen F. [Pulmonary haemodynamics during exercise and maximum tolerated power in chronic broncho-pulmonary disease] Bull Physiopathol Respir. 1974; 10(3):301-14. French.

 

Asthma and Hyperresponsiveness:

Manresa Presas F, Romero Colomer P, Rodriguez Sanchon B. Bronchial hyperreactivity in fresh stage I sarcoidosis. Ann N Y Acad Sci. 1986; 465: 523-9.

Ludwig MS, Romero PV, Bates JH. A comparison of the dose-response behavior of canine airways and parenchyma. J Appl Physiol. 1989 ; 67(3):1220-5.

Romero PV, Ludwig MS. Maximal methacholine-induced constriction in rabbit lung: interactions between airways and tissue? J Appl Physiol. 1991; 70(3): 1044-50.
Romero PV, Robatto FM, Simard S, Ludwig MS. Lung tissue behavior during methacholine challenge in rabbits in vivo. J Appl Physiol. 1992; 73(1):207-12.
Bardagi S, Agudo A, Gonzalez CA, Romero PV. Prevalence of exercise-induced airway narrowing in schoolchildren from a Mediterranean town. Am Rev Respir Dis. 1993; 147(5):1112-5.
Romero PV, Rodriguez B, Lopez-Aguilar J, Manresa F. Parallel airways inhomogeneity and lung tissue mechanics in transition to constricted state in rabbits. J Appl Physiol. 1998; 84(3):1040-7.

Romero PV, Zin WA, Lopez-Aguilar J. Frequency characteristics of lung tissue strip during passive stretch and induced pneumoconstriction. J Appl Physiol. 2001; 91(2): 882-90.

 

Respiratory Mechanics

Romero Colomer P., Manresa Presas F., Llopis Llombart R., Lopez Merino V., Rodriguez Sanchon B. Application du modéle exponentiel á l’étude des courbes pression-volume en pathologie respiratoire. Bull. Physiopath. Resp. 16: 443-458, 1980

Romero FJ, Pastor A, Lopez J, Romero PV. A recruitment-based rheological model for mechanical behavior of soft tissues. Biorheology. 1998; 35(1):17-35.

Rocco PR, Negri EM, Kurtz PM, Vasconcellos FP, Silva GH, Capelozzi VL, Romero PV, Zin WA. Lung tissue mechanics and extracellular matrix remodeling in acute lung injury. Am J Respir Crit Care Med. 2001; 164(6):1067-71.

Blanch L, Van der Kloot TE, Youngblood AM, Adams AB, Naveira A, Murias G, Romero PV, Nahum A. Selective tracheal gas insufflation during partial liquid ventilation improves lung function in an animal model of unilateral acute lung injury. Crit Care Med. 2001; 29(12):2251-7.

Romero PV, Faffe DS, Cañete C. Dynamic nonlinearity of lung tissue: frequency dependence and harmonic distortion. J Appl Physiol. 2011; 111(2):420-6.

Pinart M, Faffe DS, Romero PV. In vivo and in vitro lung mechanics by forced oscillations: effect of bleomycin challenge. Respir Physiol Neurobiol. 2012; 181(1):46-52.

 

Volumetric Capnography

Romero PV, Lucangelo U, Lopez Aguilar J, Fernandez R, BlanchL. Physiologically based indices of volumetric capnography in patients receiving mechanical ventilation. Eur Respir J. 1997; 10(6):1309-15.

Romero PV, Rodriguez B, de Oliveira D, Blanch L, Manresa F. Volumetric capnography and chronic obstructive pulmonary disease staging. Int J Chron Obstruct Pulmon Dis. 2007; 2(3):381-91.

 

Sleep Apnea

Zamarron C, Romero PV, Rodriguez JR, Gude F. Oximetry spectral analysis in the diagnosis of obstructive sleep apnoea. Clin Sci (Lond). 1999; 97(4):467-73.

Zamarron C, Gude F, Barcala J, Rodriguez JR, Romero PV. Utility of oxygen saturation and heart rate spectral analysis obtained from pulse oximetric recordings in the diagnosis of sleep apnea syndrome. Chest. 2003; 123(5):1567-76.

 

Others
Romero PV, Rodriguez B, Martinez S, Cañizares R, Sepulveda D, Manresa F. Analysis of oxidative stress in exhaled breath condensate from patients with severe pulmonary infections Arch Bronconeumol. 2006; 42(3):113-9